میزان آگاهی شما در مورد وزن گیری دوره میانسالی وسالمندی
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- MENU Nutrition & Diabetes PDFTools Appetite regulation and weight control: the role of gut hormones
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امکانات وب
The prevalence of obesity and its associated co-morbidities has increased substantially in the last number of decades, and the disease is now widely considered to be a global epidemic. Currently, among approved anti-obesity therapies, only GI surgery can effectively lead to substantial weight loss results, accompanied by long-term sustainability.129 However, GI surgery has largely been rendered impractical as a useful anti-obesity strategy, in large part due to its high cost and rate of mortality. There has, however, been increasingly convincing evidence that the resulting weight loss following the surgery is due, at least in part, to an alteration in the circulating levels and physiology of certain gut hormones.1, 63 Stimulated release of anorexigenic peptides such as CCK, PP, PYY, GLP-1, and OXM, and diminished release of the orexigenic peptide ghrelin, have been documented.63 In contrast to some of the currently used, relatively non-specific drug therapies, gut hormones function specifically on systems responsible for appetite control.129 In addition, due to their natural physiological regulation of appetite, gut hormone-based therapies are less likely to cause adverse side effects than some of the currently approved drugs,15 thus potentially offering a safer, more attractive alternative approach to combat the obesity epidemic. Although the gut-brain axis and a variety of hormone signaling pathways have been emerging as potentially powerful anti-obesity tools, the short half-life of many of the endogenous gut hormones must be considered.128, 129 Receptor agonists and alternative delivery routes have both been postulated to allow for circumvention of this unfortunate characteristic, and to aid in the future development of gut hormone-based anti-obesity therapies.15 In conclusion, continued research into the potential to pharmacologically exploit endogenously occurring appetite-regulating gut hormones in an effort to regulate energy homeostasis is required, but certainly holds great promise to lead to the development of safe and effective anti-obesity treatments, and to contribute to the effort of combating the rampant global rise in obesity. The evidence presented herein strongly indicates that obesity research and the development of weight loss or weight management products should focus on the release and function of gut hormones, in coection to their association with receptors in the CNS, in particular the hypothalamus.
nutrition and diabetes .J of nature
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نویسنده: ایلیا موسویپور